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18 July, 2004

Duane, I have redirected your query to the other CA's and the list, Hopefully someone has some ideas...


Thanks, Chris. I need a publisher, international, willing to take on this book.
Can you help me? Do you have any contacts? I need someone not in the control of the statin lobby. Duane

LIPITOR, THIEF OF MEMORY (statin drugs and the misguided war on
cholesterol) by Duane Graveline MD MPH is now available from www.spacedoc.net or www.buybooksontheweb.com Much of interest here for those taking statin drugs.

Date: Mon, 12 Jul 2004 23:00:00 -0400
To: Spacedoc@webtv.net (Duane Graveline)
From: Chris Gupta <chrisgupta@alumni.uwaterloo.ca>
Subject: Re: media contact

Great news Duane, now only if can get this into JAMA, BMJ etc.. I suspect their allegiance to the Statin ads gets in the way...

We should expose them for what they are - it gets my blood boiling as people like us, without any remuneration, have to do what they are paid to do!

Chris Gupta
List information is at: http://tinyurl.com/2xohw

At 03:38 PM 7/12/2004, Duane Graveline wrote:

The following 1200 word article, based on my book, Lipitor, Thief of Memory, will be published in the August issue of Conscious Choice Magazine out of Chicago, for newsstand circulation in Chicago, San Francisco, Vancover BC, Los Angeles and Seattle. Rebecca Ephraim,
Dragonfly Health Editor, is author. STATIN DRUGS AND MEMORY
Doctor Duane Graveline's first encounter with the frightening nightmare of transient global amnesia (TGA) occurred six weeks after he was started on Lipitor at his annual astronaut physical examination at Johnson Space Center. His cholesterol had been trending upward for several years. All was well until six weeks later when, after hs usual morning walk in the woods, his wife found him
aimlessly walking about the yard. He did not recognize her, reluctantly accepted cookies and milk and refused to go into his now unfamiliar home. He "awoke" six hours later in the office of the examining neurologist with the diagnosis of transient global amnesia, cause unknown. His MRI several days later was normal. Since Lipitor® was the only new medicine he was on, the doctor in him made him suspect a possible side effect of this drug and, despite the protestations of the
examining doctors that "statin drugs did not do this", He stopped his Lipitor®. The year passed uneventfully and soon it was time for his next astronaut physical. NASA doctors joined the chorus he had come to expect from physicians and pharmacists during the preceding year, that "statin drugs did not do this" and at their bidding he reluctantly restarted Lipitor® at one-half the previous dose. Six weeks later he again descended into the black pit of amnesia, this time for twelve hours and with a retrograde loss of memory back to his high school days. During that terrible interval, when his entire adult life had been eradicated, he had no awareness of hs marriage and four children, his medical school days, his ten adventure-filled years as a USAF flight surgeon or even his selection as
scientist astronaut. Even the names of his children were eradicated completely and he laughed at the thought of being married and a medial doctor for in his mind he was just a kid with startling recall of every other kid in my class. Many years of richly lived life had been stolen from his mind as if it never had happened. Fortunately, and typically for this obscure condition, his memory returned spontaneously and again he drove home listening to his wife's amazing tale of how his day (and hers) had gone.
Transient global amnesia is the sudden inability to formulate new memory, known as anterograde amnesia, combined with varying degrees of retrograde memory loss, sometimes for decades into the past. Until recently, the most common trigger events for these abrupt and completely unheralded amnesia cases have been sudden vigorous exercise, sex, emotional crises, cold water immersion, trauma--at times quite subtle, and cerebral angiography. In the past four years a new trigger agent has been added - the use of the stronger statin drugs such as Lipitor®, Zocor® and Mevacor®. Transient global amnesia is but the tip of the iceberg of the many other forms of statin associated memory lapses that are reported from distraught patients. Far more common are symptoms of increased senility, disorientation, confusion and unusual forgetfulness.
These lesser forms of memory impairment can be easily missed in many
individuals because, to a certain degree, that is the nature of us all.

Statin drugs, while curtailing cholesterol, must inevitably inhibit the production of other vital intermediary products that originate further down the metabolic pathway beyond the statin blockade. The pharmaceutical industry has long been attempting to develop a means by which interference with cholesterol production might be achieved beyond the point where these vital intermediary product originate but up to now have failed. The inevitability of significant, serious and even lethal side effects has been knowingly accepted.
Ubiquinone coenzyme (Q10) production is one of these collaterally damaged compounds of great concern. Biosynthesized in the mitochondria--the tiny powerhouse of the cell that is responsible for cellular respiration and energy--ubiquinone is mandatory for proper cardiac muscle function and the health and well being of every cell in our body, including muscle cells and those of peripheral nerves. In addition to statin myopathy and the more extreme form of muscle cell
damage known as rhabdomyolysis, we now are seeing peripheral neuropathy
and congestive cardiac failure from a combination of cell breakdown and
failure of mitochondrial energy production.

The dolichols are another area of collateral damage from statin use. This class of compounds are involved in an intricate process of cellular activity involving message transport known as the Golgi apparatus. Proteins manufactured there in response to DNA directives are packaged into transport vesicles that are shuttled across the cytoplasm to their various destinations. Without dolichols there would be intracellular chaos as various proteins could not be directed to their proper target and would, in effect, be dead-lettered. The post office analogy, though childishly simple, comes very close to describing dolichol function as it is understood today.

And there is more, much more. On 9 November 2001 Dr. Pfreiger of the Max Planck Society for the Advancement of Science announced to the world the discovery of the identity of the elusive synaptogenic factor responsible for the development of the highly specialized contact sites between adjacent neurons in the brain known as synapses, the basis of all brain activity. This synaptogenic factor was shown to be the notorious substance cholesterol! The glial cells of the brain are now
known to synthesize cholesterol for the specific purpose of synaptic formation and function. Stronger statins of the Lipitor, Mevacor and Zocor class easily enter the brain and interfere directly with glial cell's ability to synthesize cholesterol. This is now considered to be the likely cause of the epidemic of memory dysfunction now being noted.
There is no doubt that the present notoriety of cholesterol has all but obscured its physiological importance and necessity in our bodies. Cholesterol is not only the most common organic molecule in our brain, it is also distributed intimately
throughout our entire body. It is an essential constituent of the membrane surrounding every cell. The presence of cholesterol in this fatty double layer of the cell wall adjusts the fluid level and rigidity of this membrane to the proper value for both cell stability and function. Additionally, cholesterol is metabolized into other essential body steroids known as the steroid hormones and is therefore
the sole source for the formation of the very powerful chemicals in our body that determine our sexuality, control the reproductive process and make possible our very existence.
The pharmaceutical industry would lead us to believe that rapidly bottoming out our natural cholesterol levels through the use of their highly touted statin drugs is a relatively innocuous process of definite benefit to society. But as we learn more
each day of this ubiquitous and unique substance, we must question the veracity of their medical advisors. Cholesterol is perhaps the most important substance in our lives.
And now we are learning that statin's role in cardiovascular risk reduction may have little or nothing to do with cholesterol or LDL levels and depend instead upon anti-inflammatory mechanisms unique to this class of drugs. Surprisingly, we are discovering that our 40-year war on cholesterol through the use of drugs
and the now infamous low fat/low cholesterol diet seems to have been grossly misdirected. We have become a nation of fattened sheep, prone to type 2 diabetes and with unchanged proneness to arteriosclerosis.
Despite this rapidly growing reality, our public still remains desperately focused on cholesterol and statin sales have never been more aggressively marketed.

Doctor Duane Graveline is the author of Lipitor, Thief of Memory, from
which this material was excerpted. It can be obtained at:

LIPITOR, THIEF OF MEMORY (statin drugs and the misguided war on cholesterol) by Duane Graveline MD MPH is now available from
www.spacedoc.net or www.buybooksontheweb.com Much of interest here for
those taking statin drugs.

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